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KMID : 0438219770140010077
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Korea University Medical Journal
1977 Volume.14 No. 1 p.77 ~ p.90
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An experimental study on the influence of estrogen to tetracycline-induced hepatotoxicity
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朴文香/Park, Moon Hyang
白承龍/Paik, Seung Young
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Abstract
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There have been many reports that large doses of teracycline induce fatty infiltration of the liver in rats, and when it is given intravenously to pregnant women who have pyelonephritis, it may give rise to severe hepatic injuries.
Although the mechanism is uncertain, tetracycline in high concentration seems to impair metabolism of fat and removal of triglycerides from the liver. While the toxic effect of tetracycline in obstetric patients is known, the effect of sex hormones on liver tissue damaged by tetracycline is not understood.
The author performed biochemical and histopathologic studies to clarify the effect of estrogen on tetracycline-induced hepatic damage in male albino rats weighing about 200 grams. The experimental animal were grouped into four categories:
Group 1 , normal control group, was intraperitoneally injected with lml/day of normal saline for 4 weeks.
Group F, tetracycline administered group, was intraperitoneally injected with 75.5 mg/kg/day of tetracycline for 4 weeks.
Group I, estrogen administered group, was intramuscularly injected with 6:.25mg/kg/day of estradiol for 4 weeks.
Group N, tetracycline and estrogen combined administered group, was injected in the same manner as group I and, I in combination. for 4 weeks.
The results obtained were as follows:
1. In group I, the values of globulin (at 3rd & 4th week), T. T. T. , ammonia, total cholesterol, G. O. T. , G. P. T. and alkaline phosphatase were significantly increased more than those of the normal control group.
2. In group 1, the values of globulin (at 4th week), ammonia, total cholesterol, alkaline phosphatase, G. O. T. and G. P. T. were slightly increased more than those of the normal control group, but less than the values shown by group 1.
3. In group N, the values of ammonia, total cholesterol, alkaline phosphatase, G.O.T. and G. P. T. were slightly increased more than those of the normal control group, and revealed results similar to those of group 1, but the values were significantly lower than those shown by group j.
4 The values of protoporphyrin were especially decreased in group j , while those in group and N were observed to be similar to those of the normal control group.
5 In the histopathologc findings of the liver, hepatocytic injuries and vacuolar degeneration, which were most severe during the 1st and 2nd weeks, were observed in the test groups. There was no evidence of either cholestasis or change in bile duct epithelium.
In summary the biochemical changes of the blood (liver function test) have yieled more significant data than the histopathologic changes of the liver. Comparison of the data shows that in group j the biochemical alterations were much more significant than in group N. The results we obtained in the experiment have indicated that estrogen exerted a protective effect against tetracycline-induced hepatic dysfunction.
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KEYWORD
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